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CELLFOOD DHEA
Dehydroepiandrosterone (pronounced
dee-hi-dro-epp-ee-ann-dro-stehr-own), or DHEA as it is more often called, is
a steroid hormone naturally produced in the adrenal gland. It is the most
abundant steroid in the bloodstream and is present at even higher levels in
brain tissue. DHEA levels are known to fall precipitously with age, falling 90%
from age 20 to age 90.
DHEA is known to be a precursor to the numerous steroid sex
hormones (including estrogen and testosterone) which serve well-known functions.
Although the specific mechanisms of action for DHEA are only partially
understood, supplemental use of CELLFOOD DHEA has been shown to have anti-aging,
anti-obesity and anti-cancer influences. In addition, it is known to stabilize
nerve-cell growth and is being tested in Alzheimer’s patients.
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ABOUT
DHEA
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DHEA and Cancer
Early reports from England [Bulbrook, 1962,
1971] suggested that DHEA was abnormally low in women who developed
breast cancer, even as much as nine years prior to the onset or
diagnosis of the disease. Of the 5000 women followed in the study, 27
developed cancer. Most of the 27 had abnormally low levels of DHEA. Many
years later, Dr. Arthur Schwartz of Temple University found that
supplemental DHEA significantly protected cell cultures from the
toxicity of carcinogens. Cell cultures usually respond to powerful
carcinogens with mutations (changes in DNA), transformations (changes in
cell appearance), and a high rate of cell death. But when Schwartz added
DHEA along with the carcinogen, all three of these effects were
significantly diminished.
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DHEA and Glucose Metabolism
Investigators have shown that DHEA inhibits glucose-6-phosphate
dehydrogenase (G6PDH), an enzyme that breaks down glucose. There are two
glucose-metabolizing pathways in the body, the catabolic,
energy-yielding pathway and the anabolic, biosynthetic pathway. G6PDH
happens to be the first enzyme in the biosynthetic pathway, the one
which results in the synthesis of fatty acids and ribose (the sugar used
in making deoxyribonucleic acid, or DNA). In simple language, G6PDH
turns glucose into fat.
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DHEA and Aging
The body’s production of DHEA drops from about 30 mg at age 20 to less
than 6 mg per day at age 80. According to Dr. William Regelson of the
Medical College of Virginia, DHEA is “one of the best biochemical
bio-markers for chronologic age.” In some people, DHEA levels decline
95% during their lifetime — the largest decline of an important
biochemical yet documented.
DHEA levels are directly related to
mortality (the probability of dying) in humans. In a 12-year study of
over 240 men aged 50 to 79 years, researchers found that DHEA levels
were inversely correlated with mortality, both from heart disease and
from all causes. This finding suggests that DHEA level measurements can
become a standard diagnostic predictor of disease, mortality and
lifespan. Furthermore, if animal results hold true, supplemental DHEA
may prevent disease, reduce mortality, and extend lifespan in humans.
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DHEA: The Buffering Steroid?
DHEA may be unique among hormones for
it’s lack of specificity for hormone receptor sites. Just as vitamin E
has never been shown to have a specific metabolic role (it is only
proven essential as a general antioxidant), DHEA may serve an equally
general purpose. “DHEA is the first example of a buffer action for
hormones that I know of,” states William Regelson. “It is a
broad-acting hormone that only demonstrates itself under a specific set
of circumstances. In that way, it is like a buffer against sudden
changes in acidity or alkalinity. That is why when you get older,
you’re much more vulnerable to the effects of stress. As DHEA declines
with age, you are losing the buffer against the stress-related hormones.
It is the buffer action that [helps prevent] us from aging.” The
decrease of DHEA with age may result in gradual decline of a system for
suppressing enzyme systems responsible for creating the building blocks
of new cells, like lipids, nucleic acids (RNA and DNA) and sex steroids.
The resulting rise in enzymatic activity in advanced age may be
responsible for the proliferative events (cancer) and degenerative
disease that become more frequent in advanced age. In this respect, DHEA
might be best considered to be an anti-hormone, which might
“de-excite” steroid-sensitive receptors that would otherwise lead to
enhanced metabolic activity.
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Benefits
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Essential for healthy teeth, gums, and
bones
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Helps heal wounds, scar tissue, and bone fractures
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Prevents scurvy
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Builds resistance to infection
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Aids in the prevention and treatment
of the common cold
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Provides strength to blood vessels
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Aids in the absorption of iron
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Required for the synthesis of collagen
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Major antioxidant nutrient
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Prevents the conversion of nitrates into cancer causing substances
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May help decrease the risk of certain cancers, heart disease, and
cataracts.
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